The rise and fall of poly(ADP-ribose): An enzymatic perspective

John M. Pascal, Tom Ellenberger

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Human cells respond to DNA damage with an acute and transient burst in production of poly(ADP-ribose), a posttranslational modification that expedites damage repair and plays a pivotal role in cell fate decisions. Poly(ADP-ribose) polymerases (PARPs) and glycohydrolase (PARG) are the key set of enzymes that orchestrate the rise and fall in cellular levels of poly(ADP-ribose). In this perspective, we focus on recent structural and mechanistic insights into the enzymes involved in poly(ADP-ribose) production and turnover, and we highlight important questions that remain to be answered.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalDNA Repair
StatePublished - Aug 1 2015


  • ADP-ribose
  • DNA damage response
  • MARG
  • PARG
  • PARP
  • Poly(ADP-ribose)


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