TY - JOUR
T1 - The Return of the Mast Cell
T2 - New Roles in Neuroimmune Itch Biology
AU - Wang, Fang
AU - Yang, Ting Lin B.
AU - Kim, Brian S.
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2020/5
Y1 - 2020/5
N2 - The mast cell–nerve unit classically has represented a fundamental neuroimmune axis in the development of itch because of the traditional prominence of histamine as a pruritogen. However, it is appreciated increasingly that most chronic itch disorders are likely nonhistaminergic in nature, provoking the hypothesis that other novel effector itch mechanisms derived from mast cells are important. In this review, we present an overview of classical mast cell biology and put these concepts into the context of recent advances in our understanding of the regulation and function of the mast cell–nerve unit in itch biology.
AB - The mast cell–nerve unit classically has represented a fundamental neuroimmune axis in the development of itch because of the traditional prominence of histamine as a pruritogen. However, it is appreciated increasingly that most chronic itch disorders are likely nonhistaminergic in nature, provoking the hypothesis that other novel effector itch mechanisms derived from mast cells are important. In this review, we present an overview of classical mast cell biology and put these concepts into the context of recent advances in our understanding of the regulation and function of the mast cell–nerve unit in itch biology.
UR - http://www.scopus.com/inward/record.url?scp=85082709473&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2019.12.011
DO - 10.1016/j.jid.2019.12.011
M3 - Review article
C2 - 32248995
AN - SCOPUS:85082709473
SN - 0022-202X
VL - 140
SP - 945
EP - 951
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -