The resuscitation package in sepsis

Lee M. Demertzis, Marin H. Kollef

Research output: Contribution to journalReview articlepeer-review


Sepsis and its attendant complications are commonly encountered in the intensive care unit. Early recognition of sepsis is critical because it allows for rapid deployment of a multifaceted resuscitation package. The cornerstones of sepsis management are antibiotic therapy, source control, and hemodynamic resuscitation. In select patients, ancillary therapies are indicated, such as activated protein C, corticosteroids, and glycemic control. Given the complexity of sepsis management, optimal care can be delivered as a bundle-a protocol encompassing the above interventions. The evidence behind the various components of sepsis management are reviewed here.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalCurrent Infectious Disease Reports
Issue number5
StatePublished - Sep 2010


  • Activated protein C
  • Antibiotic therapy
  • Bundle
  • Corticosteroids
  • Glycemic control
  • Hemodynamic resuscitation
  • Management
  • Sepsis
  • Source control


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