The response of dorsal root ganglion axons to nerve growth factor gradients depends on spinal level

Irina Vetter, Zac Pujic, Geoffrey J. Goodhill

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Directed sensory axon regeneration has the potential to promote functional recovery after peripheral nerve injury. Using a novel guidance assay to generate precisely controllable nerve growth factor gradients, we show for the first time that the guidance and outgrowth response of rat dorsal root ganglion neurons to identical nerve growth factor gradients depends on the rostrocaudal origin of the dorsal root ganglion explant. These findings have implications for the study of peripheral nerve regeneration in response to exogenous neurotrophins such as nerve growth factor, and provide new insight into the clinical potential of nerve growth factor in the treatment of nerve injury.

Original languageEnglish
Pages (from-to)1379-1386
Number of pages8
JournalJournal of neurotrauma
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2010

Keywords

  • axon guidance
  • dorsal root ganglion
  • nerve growth factor
  • regeneration
  • spinal level

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