TY - JOUR
T1 - The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability
AU - Kadoglou, Nikolaos P.E.
AU - Lambadiari, Vaia
AU - Gastounioti, Aimilia
AU - Gkekas, Christos
AU - Giannakopoulos, Triantafyllos G.
AU - Koulia, Katerina
AU - Maratou, Eirini
AU - Alepaki, Maria
AU - Kakisis, John
AU - Karakitsos, Petros
AU - Nikita, Konstantina S.
AU - Dimitriadis, George
AU - Liapis, Christos D.
N1 - Publisher Copyright:
© 2014 Elsevier Ireland Ltd.
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Objective: We investigated the relationship of circulating novel adipokines, retinol-binding protein 4 (RBP4) and omentin-1, with advanced carotid atherosclerosis and ultrasound indexes of severity (total plaque area-TPA) and plaque echogenicity and vulnerability (Gray-Scale median - GSM score). Methods: We enrolled 225 patients with high-grade carotid stenosis (HGCS) who underwent carotid revascularization (73 Symptomatic patients, 152 asymptomatic patients) and 75 age- and sex-matched, asymptomatic individuals with low-grade (<50%) carotid stenosis (LGCS). Seventy-three individuals without current manifestations of atherosclerotic disease served as control group (COG). All participants underwent carotid ultrasound with TPA and GSM score assessment. Moreover, clinical parameters, metabolic profile, and circulating levels of hsCRP and adipokines were assessed. Results: RBP4 was significantly elevated in HGCS (51.44±16.23mg/L) compared to LGCS (38.39±8.85mg/L), independent of symptoms existence, whereas RBP4 levels in COG were even lower (25.74±10.72mg/L, p<0.001 compared to either HGCS or LGCS). Inversely, serum omentin-1 levels were significantly lower across HGCS (490.41±172ng/ml) and LGCS (603.20±202.43ng/ml) than COG (815.3±185.32, p<0.001). Moreover, the considerable difference between HGCS and LGCS (p<0.001) was exclusively attributed to the excessive suppression of omentin-1 concentrations in symptomatic versus asymptomatic (p=0.004) patients. HGCS and LGCS did not differ in the rest of clinical and biochemical parameters. In multiple regression analysis, RBP4 (beta=0.232, p=0.025) and hsCRP (beta=0.300, p=0.004) emerged as independent determinants of TPA in patients with carotid atherosclerosis. Low serum levels of omentin-1 correlated with GSM score and symptoms but that association was lost in multivariate analysis.. Conclusion: RBP4 serum levels were significantly elevated in patients with established carotid atherosclerosis and were positively associated with atherosclerosis severity. The association of low serum omentin-1 with carotid plaque echolucency requires further investigation.
AB - Objective: We investigated the relationship of circulating novel adipokines, retinol-binding protein 4 (RBP4) and omentin-1, with advanced carotid atherosclerosis and ultrasound indexes of severity (total plaque area-TPA) and plaque echogenicity and vulnerability (Gray-Scale median - GSM score). Methods: We enrolled 225 patients with high-grade carotid stenosis (HGCS) who underwent carotid revascularization (73 Symptomatic patients, 152 asymptomatic patients) and 75 age- and sex-matched, asymptomatic individuals with low-grade (<50%) carotid stenosis (LGCS). Seventy-three individuals without current manifestations of atherosclerotic disease served as control group (COG). All participants underwent carotid ultrasound with TPA and GSM score assessment. Moreover, clinical parameters, metabolic profile, and circulating levels of hsCRP and adipokines were assessed. Results: RBP4 was significantly elevated in HGCS (51.44±16.23mg/L) compared to LGCS (38.39±8.85mg/L), independent of symptoms existence, whereas RBP4 levels in COG were even lower (25.74±10.72mg/L, p<0.001 compared to either HGCS or LGCS). Inversely, serum omentin-1 levels were significantly lower across HGCS (490.41±172ng/ml) and LGCS (603.20±202.43ng/ml) than COG (815.3±185.32, p<0.001). Moreover, the considerable difference between HGCS and LGCS (p<0.001) was exclusively attributed to the excessive suppression of omentin-1 concentrations in symptomatic versus asymptomatic (p=0.004) patients. HGCS and LGCS did not differ in the rest of clinical and biochemical parameters. In multiple regression analysis, RBP4 (beta=0.232, p=0.025) and hsCRP (beta=0.300, p=0.004) emerged as independent determinants of TPA in patients with carotid atherosclerosis. Low serum levels of omentin-1 correlated with GSM score and symptoms but that association was lost in multivariate analysis.. Conclusion: RBP4 serum levels were significantly elevated in patients with established carotid atherosclerosis and were positively associated with atherosclerosis severity. The association of low serum omentin-1 with carotid plaque echolucency requires further investigation.
KW - Adipokines
KW - Carotid atherosclerosis
KW - Omentin-1
KW - Retinol-binding protein-4
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84919375905&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2014.05.957
DO - 10.1016/j.atherosclerosis.2014.05.957
M3 - Article
C2 - 24956535
AN - SCOPUS:84919375905
SN - 0021-9150
VL - 235
SP - 606
EP - 612
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -