@article{b4a091d4af0e4a9a8d4fb7d8ed24eec2,
title = "The relationship between spatial configuration and functional connectivity of brain regions revisited",
abstract = "Previously we showed that network-based modelling of brain connectivity interacts strongly with the shape and exact location of brain regions, such that cross-subject variations in the spatial configuration of functional brain regions are being interpreted as changes in functional connectivity (Bijsterbosch et al., 2018). Here we show that these spatial effects on connectivity estimates actually occur as a result of spatial overlap between brain networks. This is shown to systematically bias connectivity estimates obtained from group spatial ICA followed by dual regression. We introduce an extended method that addresses the bias and achieves more accurate connectivity estimates.",
author = "Bijsterbosch, {Janine Diane} and Beckmann, {Christian F.} and Woolrich, {Mark W.} and Smith, {Stephen M.} and Harrison, {Samuel J.}",
note = "Funding Information: Nederlandse Organisatie voor Wetenschappelijk Onderzoek 864.12.003 Christian F Beckmann Wellcome 098369/Z/12/Z Stephen M Smith Wellcome 091509/Z/10/Z Stephen M Smith Wellcome 203139/Z/16/Z Stephen M Smith The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Funding Information: Data were provided by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. CFB acknowledges support from The Netherlands Organization for Scientific Research (NWO, grant no 864.12.003). We are grateful for funding from the Wellcome Trust (grants 098369/Z/12/Z and 091509/Z/10/Z). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z). Publisher Copyright: {\textcopyright} Bijsterbosch et al.",
year = "2019",
month = may,
doi = "10.7554/eLife.44890",
language = "English",
volume = "8",
journal = "eLife",
issn = "2050-084X",
}