TY - JOUR
T1 - The relationship between heart rate, heart rate variability and depression in patients with coronary artery disease
AU - Carney, Robert M.
AU - Rich, Michael W.
AU - TeVelde, Adriaantje
AU - Saini, Jasbir
AU - Clark, Karen
AU - Freedland, Kenneth E.
N1 - Funding Information:
Departments of Psychiatry and Medicine, Divisions of Behavioral Washington University School of Medicine, St. Louis, MO, U.S.A. *Address reprint requests to Robert M. Carney, Department of Psychiatry, Jewish Hospital, 216 S. Kingshighway, St. Louis, MO 63110, U.S.A. tsupported in part by National Research Demonstration Center Grant, SCOR in Ischemic Heart Disease, Grant No. AH17464, National Institutes of Health, Bethesda, Maryland and a grant from the American Heart Association, St. Louis Chapter.
PY - 1988
Y1 - 1988
N2 - Seventy-seven patients undergoing elective cardiac catheterization were administered a diagnostic psychiatric interview and their mean heart rates and heart rate variability were determined from the results of a 24 hr ambulatory ECG. The mean heart rate for depressed patients with coronary artery disease (CAD) was significantly higher than for nondepressed CAD patients, independent of the patient's age, smoking status, and beta blocker therapy. Heart rate variability was lower in depressed patients but did not achieve significance. With the exception of smoking, which was more common in depressed patients, there were no significant differences between the depressed and nondepressed patients on any other medical or demographic variable assessed. It is concluded that elevated heart rate may represent increased sympathetic tone in depressed CAD patients, and may help to explain the increased morbidity and mortality reported in these patients.
AB - Seventy-seven patients undergoing elective cardiac catheterization were administered a diagnostic psychiatric interview and their mean heart rates and heart rate variability were determined from the results of a 24 hr ambulatory ECG. The mean heart rate for depressed patients with coronary artery disease (CAD) was significantly higher than for nondepressed CAD patients, independent of the patient's age, smoking status, and beta blocker therapy. Heart rate variability was lower in depressed patients but did not achieve significance. With the exception of smoking, which was more common in depressed patients, there were no significant differences between the depressed and nondepressed patients on any other medical or demographic variable assessed. It is concluded that elevated heart rate may represent increased sympathetic tone in depressed CAD patients, and may help to explain the increased morbidity and mortality reported in these patients.
UR - http://www.scopus.com/inward/record.url?scp=0023888864&partnerID=8YFLogxK
U2 - 10.1016/0022-3999(88)90050-5
DO - 10.1016/0022-3999(88)90050-5
M3 - Article
C2 - 3404497
AN - SCOPUS:0023888864
SN - 0022-3999
VL - 32
SP - 159
EP - 164
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
IS - 2
ER -