The relationship between cognitive dysfunction and symptom dimensions across schizophrenia, bipolar disorder, and major depressive disorder

Yue Zhu, Fay Y. Womer, Haixia Leng, Miao Chang, Zhiyang Yin, Yange Wei, Qian Zhou, Shinan Fu, Xin Deng, Jing Lv, Yanzhuo Song, Yinzhu Ma, Xinyu Sun, Jing Bao, Shengnan Wei, Xiaowei Jiang, Shuping Tan, Yanqing Tang, Fei Wang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Cognitive dysfunction is considered a core feature among schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Despite abundant literature comparing cognitive dysfunction among these disorders, the relationship between cognitive dysfunction and symptom dimensions remains unclear. The study aims are a) to identify the factor structure of the BPRS-18 and b) to examine the relationship between symptom domains and cognitive function across SZ, BD, and MDD. Methods: A total of 716 participants [262 with SZ, 104 with BD, 101 with MDD, and 249 healthy controls (HC)] were included in the study. One hundred eighty participants (59 with SZ, 23 with BD, 24 with MDD, and 74 HC) completed the MATRICS Consensus Cognitive Battery (MCCB), and 507 participants (85 with SZ, 89 with BD, 90 with MDD, and 243 HC) completed the Wisconsin Card Sorting Test (WCST). All patients completed the Brief Psychiatric Rating Scale (BPRS). Results: We identified five BPRS exploratory factor analysis (EFA) factors (“affective symptoms,” “psychosis,” “negative/disorganized symptoms,” “activation,” and “noncooperation”) and found cognitive dysfunction in all of the participant groups with psychiatric disorders. Negative/disorganized symptoms were the most strongly associated with cognitive dysfunctions across SZ, BD, and MDD. Conclusions: Our findings suggest that cognitive dysfunction severity relates to the negative/disorganized symptom domain across SZ, BD, and MDD, and negative/disorganized symptoms may be an important target for effective cognitive remediation in SZ, BD, and MDD.

Original languageEnglish
Article number253
JournalFrontiers in Psychiatry
Volume10
Issue numberAPR
DOIs
StatePublished - 2019

Keywords

  • Bipolar disorder
  • Cognitive function
  • Major depressive disorder
  • Schizophrenia
  • Symptom

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