The rediscovery and isolation of TFPI

G. J. Broze

doi:10.1046/j.1538-7836.2003.00391.x

The rediscovery and isolation of TFPI

G. J. Broze

Division of Hematology

Research output: Contribution to journal › Comment/debate

47 Scopus citations

Abstract

Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type proteinase inhibitor that produces factor (F)Xa-dependent feedback inhibition of the factor Vila/tissue factor (FVIIa/TF) catalytic complex that is responsible for the initiation of coagulation. Since 1985, when Rapaport and colleagues reported that the lipoprotein fraction of plasma contained a FXa-dependent inhibitor of FVIIa/TF, myriad articles have established its biochemical structure, its mechanism of action, and its physiological importance. This brief personal account reviews historical studies that established the existence of the inhibitor and the events that led to its initial isolation.

Original language	English
Pages (from-to)	1671-1675
Number of pages	5
Journal	Journal of Thrombosis and Haemostasis
Volume	1
Issue number	8
DOIs	https://doi.org/10.1046/j.1538-7836.2003.00391.x
State	Published - Aug 2003

Keywords

Factor VII
TFPI
Tissue factor

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10.1046/j.1538-7836.2003.00391.x

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AB - Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type proteinase inhibitor that produces factor (F)Xa-dependent feedback inhibition of the factor Vila/tissue factor (FVIIa/TF) catalytic complex that is responsible for the initiation of coagulation. Since 1985, when Rapaport and colleagues reported that the lipoprotein fraction of plasma contained a FXa-dependent inhibitor of FVIIa/TF, myriad articles have established its biochemical structure, its mechanism of action, and its physiological importance. This brief personal account reviews historical studies that established the existence of the inhibitor and the events that led to its initial isolation.

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KW - Tissue factor

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DO - 10.1046/j.1538-7836.2003.00391.x

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JO - Journal of Thrombosis and Haemostasis

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The rediscovery and isolation of TFPI

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