The rediscovery and isolation of TFPI

G. J. Broze

Research output: Contribution to journalComment/debate

41 Scopus citations


Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type proteinase inhibitor that produces factor (F)Xa-dependent feedback inhibition of the factor Vila/tissue factor (FVIIa/TF) catalytic complex that is responsible for the initiation of coagulation. Since 1985, when Rapaport and colleagues reported that the lipoprotein fraction of plasma contained a FXa-dependent inhibitor of FVIIa/TF, myriad articles have established its biochemical structure, its mechanism of action, and its physiological importance. This brief personal account reviews historical studies that established the existence of the inhibitor and the events that led to its initial isolation.

Original languageEnglish
Pages (from-to)1671-1675
Number of pages5
JournalJournal of Thrombosis and Haemostasis
Issue number8
StatePublished - Aug 2003


  • Factor VII
  • TFPI
  • Tissue factor


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