TY - JOUR
T1 - The QIBA profile for FDG PET/CT as an imaging biomarker measuring response to cancer therapy
AU - Kinahan, Paul E.
AU - Perlman, Eric S.
AU - Sunderland, John J.
AU - Subramaniam, Rathan
AU - Wollenweber, Scott D.
AU - Turkington, Timothy G.
AU - Lodge, Martin A.
AU - Boellaard, Ronald
AU - Obuchowski, Nancy A.
AU - Wahl, Richard L.
N1 - Publisher Copyright:
© RSNA, 2020
PY - 2020
Y1 - 2020
N2 - The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims on the precision of SUV measurements. First, tumor glycolytic activity as reflected by the maximum SUV (SUVmax) is measurable from FDG PET/CT with a within-subject coefficient of variation of 10%–12%. Second, a measured increase in SUVmax of 39% or more, or a decrease of 28% or more, indicates that a true change has occurred with 95% confidence. Two applicable use cases are clinical trials and following individual patients in clinical practice. Other components of the Profile address the protocols and conformance standards considered necessary to achieve the performance claim. The Profile is intended for use by a broad audience; applications can range from discovery science through clinical trials to clinical practice. The goal of this report is to provide a rationale and overview of the FDG PET/CT Profile claims as well as its context, and to outline future needs and potential developments.
AB - The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims on the precision of SUV measurements. First, tumor glycolytic activity as reflected by the maximum SUV (SUVmax) is measurable from FDG PET/CT with a within-subject coefficient of variation of 10%–12%. Second, a measured increase in SUVmax of 39% or more, or a decrease of 28% or more, indicates that a true change has occurred with 95% confidence. Two applicable use cases are clinical trials and following individual patients in clinical practice. Other components of the Profile address the protocols and conformance standards considered necessary to achieve the performance claim. The Profile is intended for use by a broad audience; applications can range from discovery science through clinical trials to clinical practice. The goal of this report is to provide a rationale and overview of the FDG PET/CT Profile claims as well as its context, and to outline future needs and potential developments.
UR - http://www.scopus.com/inward/record.url?scp=85080847353&partnerID=8YFLogxK
U2 - 10.1148/radiol.2019191882
DO - 10.1148/radiol.2019191882
M3 - Article
C2 - 31909700
AN - SCOPUS:85080847353
SN - 0033-8419
VL - 294
SP - 647
EP - 657
JO - Radiology
JF - Radiology
IS - 2
ER -