@article{42dec2fe4ee347a1863a214a1f6ce7a0,
title = "The proteome of clear cell ovarian carcinoma",
abstract = "Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late-stage CCOC is not responsive to gold-standard chemotherapy and results in suboptimal outcomes for patients. In-depth molecular insight is urgently needed to stratify the disease and drive therapeutic development. We conducted global proteomics for 192 cases of CCOC and compared these with other epithelial ovarian carcinoma subtypes. Our results showed distinct proteomic differences in CCOC compared with other epithelial ovarian cancer subtypes including alterations in lipid and purine metabolism pathways. Furthermore, we report potential clinically significant proteomic subgroups within CCOC, suggesting the biologic plausibility of stratified treatment for this cancer. Taken together, our results provide a comprehensive understanding of the CCOC proteomic landscape to facilitate future understanding and research of this disease.",
keywords = "clear cell ovarian carcinoma, endometrioid ovarian carcinoma, epithelial ovarian carcinoma, high-grade serous ovarian carcinoma, immunohistochemistry, proteomics",
author = "Ji, {Jennifer X.} and Cochrane, {Dawn R.} and Negri, {Gian Luca} and Shane Colborne and {Spencer Miko}, {Sandra E.} and Hoang, {Lynn N.} and David Farnell and Basile Tessier-Cloutier and Jutta Huvila and Emily Thompson and Samuel Leung and Derek Chiu and Christine Chow and Monica Ta and Martin K{\"o}bel and Lucas Feil and Michael Anglesio and Goode, {Ellen L.} and Kelly Bolton and Morin, {Gregg B.} and Huntsman, {David G.}",
note = "Funding Information: This study was supported by grants from the Canadian Cancer Society (Impact grant #705647) and the Canadian Institutes of Health Research (Foundation grant #154290). The VGH and UBC Hospital Foundation and the BC Cancer Foundation provided funding to OVCARE: British Columbia's Ovarian Cancer Research Team. This study used resources provided by the Canadian Ovarian Cancer Research Consortium's COEUR biobank funded by the Terry Fox Research Institute and Ovarian Cancer Canada, and managed by the Centre de recherche du Centre hospitalier de l'Universit{\'e} de Montr{\'e}al (CRCHUM); the COEUR biobank recognizes the contribution of institutions across Canada (for a full list see https://www.tfri.ca/coeur) and is affiliated with the Canadian Tissue Repository Network. We thank the molecular pathology core facility of the CRCHUM, and in particular Liliane Meunier, for sample processing. JXJ is supported by a Vanier Canada graduate scholarship and UBC-BCCA MD/PhD studentship. DH is supported by the Dr. Chew Wei Memorial Professorship in Gynecologic Oncology and the Canada Research Chairs program (Research Chair in Molecular and Genomic Pathology). We would like to thank all patients who have donated samples to the tumour banks to support gynecological cancer research. We would also like to thank Dr Nissreen Mohammad for help with scoring TMAs. Funding Information: This study was supported by grants from the Canadian Cancer Society (Impact grant #705647) and the Canadian Institutes of Health Research (Foundation grant #154290). The VGH and UBC Hospital Foundation and the BC Cancer Foundation provided funding to OVCARE: British Columbia's Ovarian Cancer Research Team. This study used resources provided by the Canadian Ovarian Cancer Research Consortium's COEUR biobank funded by the Terry Fox Research Institute and Ovarian Cancer Canada, and managed by the Centre de recherche du Centre hospitalier de l'Universit{\'e} de Montr{\'e}al (CRCHUM); the COEUR biobank recognizes the contribution of institutions across Canada (for a full list see https://www.tfri.ca/coeur ) and is affiliated with the Canadian Tissue Repository Network. We thank the molecular pathology core facility of the CRCHUM, and in particular Liliane Meunier, for sample processing. JXJ is supported by a Vanier Canada graduate scholarship and UBC‐BCCA MD/PhD studentship. DH is supported by the Dr. Chew Wei Memorial Professorship in Gynecologic Oncology and the Canada Research Chairs program (Research Chair in Molecular and Genomic Pathology). We would like to thank all patients who have donated samples to the tumour banks to support gynecological cancer research. We would also like to thank Dr Nissreen Mohammad for help with scoring TMAs. Publisher Copyright: {\textcopyright} 2022 The Pathological Society of Great Britain and Ireland.",
year = "2022",
month = dec,
doi = "10.1002/path.6006",
language = "English",
volume = "258",
pages = "325--338",
journal = "Journal of Pathology",
issn = "0022-3417",
number = "4",
}