The Protein 4.1 tumor suppressor, DAL-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion

David H. Gutmann, Angela C. Hirbe, Zhi Yong Huang, Carrie A. Haipek

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The neurofibromatosis 2 (NF2) tumor suppressor belongs to the Protein 4.1 family of molecules that link the actin cytoskeleton to cell surface glycoproteins. We have previously demonstrated that the NF2 protein, merlin, can suppress cell growth in vitro and in vivo as well as impair actin cytoskeleton-associated processes, such as cell spreading, attachment, and motility. Recently, we determined that expression of a second Protein 4.1 tumor suppressor, DAL-1, was lost in 60% of sporadic meningiomas, but not schwannomas. In this report, we demonstrate that DAL-1 suppresses cell proliferation in meningioma, but not schwannoma cells. Similar to merlin, DAL-1 interacts with other ERM proteins and βII-spectrin, but not the merlin interactor protein, SCHIP-1. In addition, we report the, identification of the full-length DAL-1 tumor suppressor, termed KIAA0987. Collectively, these results suggest that the two Protein 4.1 meningioma tumor suppressors, merlin and DAL-1, may be functionally distinct proteins with different mechanisms of action.

Original languageEnglish
Pages (from-to)266-278
Number of pages13
JournalNeurobiology of Disease
Volume8
Issue number2
DOIs
StatePublished - 2001

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