The protective effects of ligustrazine on ischemia-reperfusion and DPPH free radical-induced myocardial injury in isolated rat hearts

Yuan Zhou, Chang Ping Hu, Pan Yue Deng, Han Wu Deng, Yuan Jian Li

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Previous investigations have suggested that tumor necrosis factor-alpha (INF-α) can contribute to myocardial damage during ischemia-reperfusion. In the present study, we examined whether the cardioprotective effects of ligustrazine are related to inhibition of TNF-α production in the rat models of ischemia-reperfusion and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-induced myocardial injury. Ischemia for 20 min and reperfusion for 40 min caused a decline in cardiac function (left ventricular pressure, ± dp/dtmax, heart rate and coronary flow) and an increase in the release of creatine kinase in coronary effluent and the content of TNF-α in myocardial tissues. Similarly, perfusion with 1 DPPH (100 nM) for 30 min significantly decreased cardiac function, and increased the release of creatine kinase and the content of TNF-α. Ligustrazine at the concentration of 40 or 80 mg/L markedly improved cardiac function and reduced the release of creatine kinase and the content of TNF-α in myocardial tissues in hearts subjected to ischemia-reperfusion or DPPH perfusion. These results suggest that the cardioprotection afforded by ligustrazine is related to a reduction of TNF-α content by inhibition of free radical production in isolated rat hearts.

Original languageEnglish
Pages (from-to)818-822
Number of pages5
JournalPlanta Medica
Volume70
Issue number9
DOIs
StatePublished - Sep 2004

Keywords

  • 1,1-diphenyl-2-picrylhydrazyl
  • Apiaceae
  • Ligusticum wallichii
  • Ligustrazine
  • Myocardial ischemia-reperfusion injury
  • Rat isolated heart
  • Tumor necrosis factor-alpha

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