TY - JOUR
T1 - The Protective Effect of Familial Longevity Persists After Age 100
T2 - Findings From the Danish National Registers
AU - Galvin, Angéline
AU - Pedersen, Jacob Krabbe
AU - Wojczynski, Mary K.
AU - Ukraintseva, Svetlana
AU - Arbeev, Konstantin
AU - Feitosa, Mary
AU - Province, Michael A.
AU - Christensen, Kaare
N1 - Publisher Copyright:
© 2023 The Author(s). Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Background: A recent study suggested that the protective effect of familial longevity becomes negligible for centenarians. However, the authors assessed the dependence on familial longevity in centenarians by comparing centenarians with 1 parent surviving to age 80+ to centenarians whose same-sexed parent did not survive to age 80. Here we test whether the protective effect of familial longevity persists after age 100 using more restrictive definitions of long-lived families. Methods: Long-lived sibships were identified through 3 nationwide, consecutive studies in Denmark, including families with either at least 2 siblings aged 90+ or a Family Longevity Selection Score (FLoSS) above 7. Long-lived siblings enrolled in these studies and who reached age 100 were included. For each sibling, 5 controls matched on sex and year of birth were randomly selected among centenarians in the Danish population. Survival time from age 100 was described with Kaplan-Meier curves for siblings and controls separately. Survival analyses were performed using stratified Cox proportional hazards models. Results: A total of 340 individuals from long-lived sibships who survived to age 100 and 1 700 controls were included. Among the long-lived siblings and controls, 1 650 (81%) were women. The results showed that long-lived siblings presented better overall survival after age 100 than sporadic long-livers (hazard ratio [HR] = 0.80, 95% confidence interval [CI] = 0.71-0.91), with even lower estimate (HR = 0.65, 95% CI = 0.50- 0.85) if familial longevity was defined by FLoSS. Conclusions: The present study, with virtually no loss to follow-up, demonstrated a persistence of protective effect of familial longevity after age 100.
AB - Background: A recent study suggested that the protective effect of familial longevity becomes negligible for centenarians. However, the authors assessed the dependence on familial longevity in centenarians by comparing centenarians with 1 parent surviving to age 80+ to centenarians whose same-sexed parent did not survive to age 80. Here we test whether the protective effect of familial longevity persists after age 100 using more restrictive definitions of long-lived families. Methods: Long-lived sibships were identified through 3 nationwide, consecutive studies in Denmark, including families with either at least 2 siblings aged 90+ or a Family Longevity Selection Score (FLoSS) above 7. Long-lived siblings enrolled in these studies and who reached age 100 were included. For each sibling, 5 controls matched on sex and year of birth were randomly selected among centenarians in the Danish population. Survival time from age 100 was described with Kaplan-Meier curves for siblings and controls separately. Survival analyses were performed using stratified Cox proportional hazards models. Results: A total of 340 individuals from long-lived sibships who survived to age 100 and 1 700 controls were included. Among the long-lived siblings and controls, 1 650 (81%) were women. The results showed that long-lived siblings presented better overall survival after age 100 than sporadic long-livers (hazard ratio [HR] = 0.80, 95% confidence interval [CI] = 0.71-0.91), with even lower estimate (HR = 0.65, 95% CI = 0.50- 0.85) if familial longevity was defined by FLoSS. Conclusions: The present study, with virtually no loss to follow-up, demonstrated a persistence of protective effect of familial longevity after age 100.
KW - Aging
KW - Centenarians
KW - Familial longevity
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85180533180&partnerID=8YFLogxK
U2 - 10.1093/gerona/glad164
DO - 10.1093/gerona/glad164
M3 - Article
C2 - 37449765
AN - SCOPUS:85180533180
SN - 1079-5006
VL - 79
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 1
M1 - glad164
ER -