TY - JOUR
T1 - The prospective association between periodontal disease and brain imaging outcomes
T2 - The Atherosclerosis Risk in Communities study
AU - Adam, Hamdi S.
AU - Lakshminarayan, Kamakshi
AU - Wang, Wendy
AU - Norby, Faye L.
AU - Mosley, Thomas
AU - Walker, Keenan A.
AU - Gottesman, Rebecca F.
AU - Meyer, Katie
AU - Hughes, Timothy M.
AU - Pankow, James S.
AU - Wong, Dean F.
AU - Jack, Clifford R.
AU - Sen, Souvik
AU - Lutsey, Pamela L.
AU - Beck, Jim
AU - Demmer, Ryan T.
N1 - Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2022/4
Y1 - 2022/4
N2 - Aim: We investigate if periodontal disease is prospectively associated with cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology. Materials and Methods: N = 1306 participants (Visit 5 mean age = 76.5 [standard deviation = 5.4] years) in the Atherosclerosis Risk in Communities study with completed dental exams at Visit 4 underwent brain magnetic resonance imaging scans at Visit 5 while N = 248 underwent positron emission tomography scans. Participants were classified as edentulous or, among the dentate, by the modified Periodontal Profile Class. Brain volumes were regressed on periodontal status in linear regressions. Cerebrovascular measures and β-amyloid positivity were regressed on periodontal status in logistic regressions. Results: Periodontal disease was not associated with brain volumes, microhaemorrhages, or elevated β-amyloid. Compared with periodontally healthy individuals, odds ratios [95% confidence interval] for all-type infarcts were 0.37 [0.20, 0.65] for severe tooth loss and 0.56 [0.31, 0.99] for edentulous participants. Conclusions: Within the limitations of this study, periodontal disease was not associated with altered brain volumes, microhaemorrhages, or β-amyloid positivity. Tooth loss was associated with lower odds of cerebral infarcts.
AB - Aim: We investigate if periodontal disease is prospectively associated with cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology. Materials and Methods: N = 1306 participants (Visit 5 mean age = 76.5 [standard deviation = 5.4] years) in the Atherosclerosis Risk in Communities study with completed dental exams at Visit 4 underwent brain magnetic resonance imaging scans at Visit 5 while N = 248 underwent positron emission tomography scans. Participants were classified as edentulous or, among the dentate, by the modified Periodontal Profile Class. Brain volumes were regressed on periodontal status in linear regressions. Cerebrovascular measures and β-amyloid positivity were regressed on periodontal status in logistic regressions. Results: Periodontal disease was not associated with brain volumes, microhaemorrhages, or elevated β-amyloid. Compared with periodontally healthy individuals, odds ratios [95% confidence interval] for all-type infarcts were 0.37 [0.20, 0.65] for severe tooth loss and 0.56 [0.31, 0.99] for edentulous participants. Conclusions: Within the limitations of this study, periodontal disease was not associated with altered brain volumes, microhaemorrhages, or β-amyloid positivity. Tooth loss was associated with lower odds of cerebral infarcts.
KW - cohort studies
KW - dementia
KW - magnetic resonance imaging
KW - periodontal diseases
KW - positron-emission tomography
UR - http://www.scopus.com/inward/record.url?scp=85123679396&partnerID=8YFLogxK
U2 - 10.1111/jcpe.13586
DO - 10.1111/jcpe.13586
M3 - Article
C2 - 34905804
AN - SCOPUS:85123679396
SN - 0303-6979
VL - 49
SP - 322
EP - 334
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 4
ER -