The proportion and size of GABA-immunoreactive neurons in the magnocellular and parvocellular layers of the lateral geniculate nucleus of the rhesus monkey

V. M. Montero, J. Zempel

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Neurons containing GABA-immunoreactivity in LGN of the macaque monkey were analyzed quantitatively in semithin (1 μm) sections. The percentage of GABA(+) cells per unit area of the sections was 26% in the magnocellular layers and 19% in the parvocellular layers. However, the percentage of GABA(+) cells in a unit volume of LGN, calculated by a stereological method that takes into account the observed difference in size of labeled and unlabeled somata, was 35% in the magnocellular layers and 25% in the parvocellular layers. GABA(+) somata in the magnocellular layers were significantly larger than those in the parvocellular layers. The possible role of GABAergic cells in inhibitory mechanisms of receptive fields of parvo- and magnocellular neurons are discussed in the light of current knowledge of the physiology and neural circuits of macaque LGN.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalExperimental Brain Research
Volume62
Issue number1
DOIs
StatePublished - Mar 1 1986
Externally publishedYes

Keywords

  • Dorsal lateral geniculate nucleus
  • GABA
  • Immunocytochemistry
  • Inhibition
  • Interneurons

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