The product of SPO1 gene 56 inhibits host cell division during infection of Bacillus subtilis by bacteriophage SPO1

Charles R. Stewart, William J. Deery, Elie S.K. Egan, Bati Myles, Allegra A. Petti

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Although cells of Bacillus subtilis continue to grow after being infected by bacteriophage SPO1, they do not undergo cell division. The product of SPO1 gene 56 is necessary and sufficient for this inhibition of cell division. GP56 inhibits cell division when expressed in uninfected B. subtilis, without preventing cell growth, DNA synthesis or chromosome segregation, ultimately causing filamentation and loss of viability. During infection, a gene 56 mutation prevents the inhibition of cell division that occurs in wild-type infection. Under the laboratory conditions used, the gene 56 mutation did not affect burst size, latent period, or other components of the host-takeover process.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalVirology
Volume447
Issue number1-2
DOIs
StatePublished - Dec 2013

Keywords

  • B. subtilis phage
  • Bacteriophage SPO1
  • Host-takeover
  • Inhibition of cell division
  • SPO1 gene 56

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