The pressure recovery ratio: The invasive index of LV relaxation during filling. Model-based prediction with in-Vivo validation

Wei Zhang, Leonid Shmuylovich, Sándor J. Kovács

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using a simple harmonic oscillator model (PDF formalism), every early filling E-wave can be uniquely described by a set of parameters, (xo, c, and k). Parameter c in the PDF formalism is a damping or relaxation parameter that measures the energy loss during the filling process. Based on Bernoulli's equation and kinematic modeling, we derived a causal correlation between the relaxation parameter c in the PDF formalism and a feature of the pressure contour during filling - the pressure recovery ratio defined by the left ventricular pressure difference between diastasis and minimum pressure, normalized to the pressure difference between a fiducial pressure and minimum pressure [PRR=(PDiastasis-PMin)/(PFiducial- PMin)]. We analyzed multiple heart beats from one human subject to validate the correlation. Further validation among more patients is warranted. PRR is the invasive causal analogue of the noninvasive E-wave relaxation parameter c. PRR has the potential to be calculated using automated methodology in the catheterization lab in real time.

Original languageEnglish
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages3940-3943
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - Jan 1 2009
Externally publishedYes
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Conference

Conference31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period09/2/0909/6/09

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  • Cite this

    Zhang, W., Shmuylovich, L., & Kovács, S. J. (2009). The pressure recovery ratio: The invasive index of LV relaxation during filling. Model-based prediction with in-Vivo validation. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 3940-3943). [5333092] (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5333092