The Predictive Value of Bronchiolitis Obliterans Syndrome Stage 0-p

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Abstract

Bronchiolitis obliterans syndrome (BOS) remains the main cause of graft loss after lung transplantation. Stage 0-p was recently added to the staging criteria to detect early deterioration in allograft function that might presage BOS stage 1. We assessed the predictive value of stage 0-p by retrospectively analyzing spirometric data for 203 adult bilateral lung transplant recipients. The FEV1 criterion for stage 0-p had a positive predictive value of 79% and a negative predictive value of 82%. In contrast, the FEF 25-75% criterion for stage 0-p had a positive predictive value of 52% and a negative predictive value of 72%. Fifty-seven percent of subjects who developed stage 0-p by the FEV1 criterion progressed to stage 1 within 1 year, whereas only 37% of those who developed stage 0-p by the FEF 25-75% criterion progressed to stage 1 within 1 year. We conclude that the FEV1 criterion for stage 0-p is a reasonable predictor of BOS stage 1 after bilateral lung transplantation, but the FEF25-75% criterion for stage 0-p is not predictive of BOS stage 1 after bilateral lung transplantation.

Original languageEnglish
Pages (from-to)468-472
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Volume169
Issue number4
DOIs
StatePublished - Feb 15 2004

Keywords

  • Chronic rejection
  • Diagnosis
  • Lung transplantation
  • Spirometry

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