The predictability of the histological features of uremic bone disease by non-invasive techniques

Keith A. Hruska, Steven L. Teitelbaum, Robert Kopelman, Catherine A. Richardson, Philip Miller, James Debman, Kevin Martin, Eduardo Slatopolsky

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Forty-six uremic patients on chronic hemodialysis underwent bone biopsy to ascertain the relationships of serum biochemistry, radiographic analysis, and bone mineral analysis to bone histomorphometry. Circulating levels of immunoreactive parathyroid hormone and alkaline phosphatase, as well as radiographically apparent subperiosteal resorption, are most predictive of osteitis fibrosa. Bone densitometry correlated poorly with some parameters of osteitis fibrosa and not with histologically measured bone volume. None of the clinical parameters tested are predictive of osteomalacia. These findings underscore the necessity of bone biopsy to accurately assess the chronically uremic skeleton.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalMetabolic Bone Disease and Related Research
Volume1
Issue number1
DOIs
StatePublished - 1978

Keywords

  • Bone Biopsy
  • Bone Morphometry
  • Hyperparathyroidism
  • Osteomalacia
  • Serum Biochemistry

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