TY - JOUR
T1 - The predictability of the histological features of uremic bone disease by non-invasive techniques
AU - Hruska, Keith A.
AU - Teitelbaum, Steven L.
AU - Kopelman, Robert
AU - Richardson, Catherine A.
AU - Miller, Philip
AU - Debman, James
AU - Martin, Kevin
AU - Slatopolsky, Eduardo
N1 - Funding Information:
Acknowledgements: This work was supported by U.S.P.H.S. NIAMDD grants AM-09976, AM-05248 AM-11674. and Division of Research Resources, General Clinical Research Centers Branch, NIH grant 5MOlRR00036-15. Dr. Kevin Martin was supported by a Fellowship Grant from the National Kidney Foundation during the course of this study.
PY - 1978
Y1 - 1978
N2 - Forty-six uremic patients on chronic hemodialysis underwent bone biopsy to ascertain the relationships of serum biochemistry, radiographic analysis, and bone mineral analysis to bone histomorphometry. Circulating levels of immunoreactive parathyroid hormone and alkaline phosphatase, as well as radiographically apparent subperiosteal resorption, are most predictive of osteitis fibrosa. Bone densitometry correlated poorly with some parameters of osteitis fibrosa and not with histologically measured bone volume. None of the clinical parameters tested are predictive of osteomalacia. These findings underscore the necessity of bone biopsy to accurately assess the chronically uremic skeleton.
AB - Forty-six uremic patients on chronic hemodialysis underwent bone biopsy to ascertain the relationships of serum biochemistry, radiographic analysis, and bone mineral analysis to bone histomorphometry. Circulating levels of immunoreactive parathyroid hormone and alkaline phosphatase, as well as radiographically apparent subperiosteal resorption, are most predictive of osteitis fibrosa. Bone densitometry correlated poorly with some parameters of osteitis fibrosa and not with histologically measured bone volume. None of the clinical parameters tested are predictive of osteomalacia. These findings underscore the necessity of bone biopsy to accurately assess the chronically uremic skeleton.
KW - Bone Biopsy
KW - Bone Morphometry
KW - Hyperparathyroidism
KW - Osteomalacia
KW - Serum Biochemistry
UR - http://www.scopus.com/inward/record.url?scp=0002729096&partnerID=8YFLogxK
U2 - 10.1016/0221-8747(78)90035-8
DO - 10.1016/0221-8747(78)90035-8
M3 - Article
AN - SCOPUS:0002729096
SN - 0221-8747
VL - 1
SP - 39
EP - 44
JO - Metabolic Bone Disease and Related Research
JF - Metabolic Bone Disease and Related Research
IS - 1
ER -