The PPAR regulatory system in cardiac physiology and disease

Brian N. Finck

doi:10.1016/j.cardiores.2006.08.023

The PPAR regulatory system in cardiac physiology and disease

Brian N. Finck

Research output: Contribution to journal › Review article › peer-review

182 Scopus citations

Abstract

Myocardial energy metabolism is an important determinant of cardiac structure and function. Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac disease. The peroxisome proliferator-activated receptor family (PPARα, β/δ, γ) of nuclear receptor transcription factors is an important regulator of cardiac metabolism and has been targeted for pharmacologic therapies designed to modulate metabolism. The PPARs control myocardial metabolism by transcriptionally regulating genes encoding enzymes involved in fatty acid and glucose utilization. The expression and activity of the PPARs and their coactivator protein PGC-1α is dynamically regulated in several cardiomyopathic and metabolic diseases. This review will summarize these findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling.

Original language	English
Pages (from-to)	269-277
Number of pages	9
Journal	Cardiovascular Research
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/j.cardiores.2006.08.023
State	Published - Jan 15 2007

Keywords

Diabetes
Energy metabolism
Lipid metabolism
Mitochondria
Transgenic animal models

Access to Document

10.1016/j.cardiores.2006.08.023

Cite this

@article{7a7c69ed0a5248369bfa5ad2450c5d7a,

title = "The PPAR regulatory system in cardiac physiology and disease",

abstract = "Myocardial energy metabolism is an important determinant of cardiac structure and function. Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac disease. The peroxisome proliferator-activated receptor family (PPARα, β/δ, γ) of nuclear receptor transcription factors is an important regulator of cardiac metabolism and has been targeted for pharmacologic therapies designed to modulate metabolism. The PPARs control myocardial metabolism by transcriptionally regulating genes encoding enzymes involved in fatty acid and glucose utilization. The expression and activity of the PPARs and their coactivator protein PGC-1α is dynamically regulated in several cardiomyopathic and metabolic diseases. This review will summarize these findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling.",

keywords = "Diabetes, Energy metabolism, Lipid metabolism, Mitochondria, Transgenic animal models",

author = "Finck, {Brian N.}",

note = "Funding Information: Several acquired forms of cardiomyopathy are associated with a decline in overall mitochondrial oxidative catabolism while reliance on anaerobic glycolytic pathways is increased [1,2,4–7]. Whereas altered metabolism was originally considered to be a byproduct of these pathologic states, evidence is emerging that metabolic abnormalities contribute to the pathogenesis of cardiac disease. This idea is supported by",

year = "2007",

month = jan,

day = "15",

doi = "10.1016/j.cardiores.2006.08.023",

language = "English",

volume = "73",

pages = "269--277",

journal = "Cardiovascular Research",

issn = "0008-6363",

number = "2",

}

TY - JOUR

T1 - The PPAR regulatory system in cardiac physiology and disease

AU - Finck, Brian N.

N1 - Funding Information: Several acquired forms of cardiomyopathy are associated with a decline in overall mitochondrial oxidative catabolism while reliance on anaerobic glycolytic pathways is increased [1,2,4–7]. Whereas altered metabolism was originally considered to be a byproduct of these pathologic states, evidence is emerging that metabolic abnormalities contribute to the pathogenesis of cardiac disease. This idea is supported by

PY - 2007/1/15

Y1 - 2007/1/15

N2 - Myocardial energy metabolism is an important determinant of cardiac structure and function. Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac disease. The peroxisome proliferator-activated receptor family (PPARα, β/δ, γ) of nuclear receptor transcription factors is an important regulator of cardiac metabolism and has been targeted for pharmacologic therapies designed to modulate metabolism. The PPARs control myocardial metabolism by transcriptionally regulating genes encoding enzymes involved in fatty acid and glucose utilization. The expression and activity of the PPARs and their coactivator protein PGC-1α is dynamically regulated in several cardiomyopathic and metabolic diseases. This review will summarize these findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling.

AB - Myocardial energy metabolism is an important determinant of cardiac structure and function. Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac disease. The peroxisome proliferator-activated receptor family (PPARα, β/δ, γ) of nuclear receptor transcription factors is an important regulator of cardiac metabolism and has been targeted for pharmacologic therapies designed to modulate metabolism. The PPARs control myocardial metabolism by transcriptionally regulating genes encoding enzymes involved in fatty acid and glucose utilization. The expression and activity of the PPARs and their coactivator protein PGC-1α is dynamically regulated in several cardiomyopathic and metabolic diseases. This review will summarize these findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling.

KW - Diabetes

KW - Energy metabolism

KW - Lipid metabolism

KW - Mitochondria

KW - Transgenic animal models

UR - http://www.scopus.com/inward/record.url?scp=33845577985&partnerID=8YFLogxK

U2 - 10.1016/j.cardiores.2006.08.023

DO - 10.1016/j.cardiores.2006.08.023

M3 - Review article

C2 - 17010956

AN - SCOPUS:33845577985

SN - 0008-6363

VL - 73

SP - 269

EP - 277

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 2

ER -

The PPAR regulatory system in cardiac physiology and disease

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this