The power of the few

Ran Chen; Yuan Pan; David H. Gutmann

doi:10.1101/gad.303453.117

The power of the few

Ran Chen, Yuan Pan, David H. Gutmann

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Converging evidence from numerous laboratories has revealed that malignant brain cancers are complex ecological systems composed of distinct cellular and acellular elements that collectively dictate glioblastoma biology. Our understanding of the individual contributions of each of these components is vital to the design of effective therapies against these cancers. In this issue of Genes & Development, Zanca and colleagues (pp. 1212-1227) demonstrate that one subpopulation of glioblastoma cells expressing a mutant epidermal growth factor receptor (EGFRvIII) is responsible for the survival of non-EGFR-vIII-expressing tumor cells as well as for evading molecularly targeted therapy.

Original language	English
Pages (from-to)	1177-1179
Number of pages	3
Journal	Genes and Development
Volume	31
Issue number	12
DOIs	https://doi.org/10.1101/gad.303453.117
State	Published - Jun 15 2017

Keywords

EGFR
Glioblastoma
IL-6
NF-κB
Survivin
Tumor heterogeneity

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abstract = "Converging evidence from numerous laboratories has revealed that malignant brain cancers are complex ecological systems composed of distinct cellular and acellular elements that collectively dictate glioblastoma biology. Our understanding of the individual contributions of each of these components is vital to the design of effective therapies against these cancers. In this issue of Genes & Development, Zanca and colleagues (pp. 1212-1227) demonstrate that one subpopulation of glioblastoma cells expressing a mutant epidermal growth factor receptor (EGFRvIII) is responsible for the survival of non-EGFR-vIII-expressing tumor cells as well as for evading molecularly targeted therapy.",

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The power of the few

Abstract

Keywords

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