TY - JOUR
T1 - The Plasmodium digestive Vacuole
T2 - Metabolic Headquarters and Choice Drug Target
AU - Olliaro, P. L.
AU - Goldberg, D. E.
N1 - Funding Information:
The authors thank Francesco Caste11(1U nlverslty of Brescla. Italy) for-kind collaboration and Andy Grump CTDR) for technlcal support. Pat-t of this work was supported by fundlng from the Charles E. Culpeper Foundation, NlAlD #AI-3 I6 15,t he WashIngton Unlvenlty-Monsantoi Seariec ooperative agreement,a nd the Howard Hughes MedIcal lnstltute.
PY - 1995/8
Y1 - 1995/8
N2 - The Plasmodium digestive (food) vacuole is an acidic proteolytic compartment central to the metabolism of the parasite. Here haemoglobin is degraded, haem is polymerized, amino acid are transported, oxygen radicals are detoxified, drugs are accumulated, acidification is maintained and free iron may be generated. Despite these crucial roles in parasite development, a number of questions about the digestive vacuole and the haemoglobin ingestion pathway remain unanswered; in consequence, a number of attractive drug targets remain to be exploited. Piero Olliaro and Daniel Goldberg here review the morphology, metabolism and pharmacological disruption of this specialized organelle.
AB - The Plasmodium digestive (food) vacuole is an acidic proteolytic compartment central to the metabolism of the parasite. Here haemoglobin is degraded, haem is polymerized, amino acid are transported, oxygen radicals are detoxified, drugs are accumulated, acidification is maintained and free iron may be generated. Despite these crucial roles in parasite development, a number of questions about the digestive vacuole and the haemoglobin ingestion pathway remain unanswered; in consequence, a number of attractive drug targets remain to be exploited. Piero Olliaro and Daniel Goldberg here review the morphology, metabolism and pharmacological disruption of this specialized organelle.
UR - http://www.scopus.com/inward/record.url?scp=0029013807&partnerID=8YFLogxK
U2 - 10.1016/0169-4758(95)80042-5
DO - 10.1016/0169-4758(95)80042-5
M3 - Review article
C2 - 15275326
AN - SCOPUS:0029013807
SN - 0169-4758
VL - 11
SP - 294
EP - 297
JO - Parasitology Today
JF - Parasitology Today
IS - 8
ER -