The Plasmodium digestive Vacuole: Metabolic Headquarters and Choice Drug Target

P. L. Olliaro, D. E. Goldberg

Research output: Contribution to journalReview articlepeer-review

143 Scopus citations

Abstract

The Plasmodium digestive (food) vacuole is an acidic proteolytic compartment central to the metabolism of the parasite. Here haemoglobin is degraded, haem is polymerized, amino acid are transported, oxygen radicals are detoxified, drugs are accumulated, acidification is maintained and free iron may be generated. Despite these crucial roles in parasite development, a number of questions about the digestive vacuole and the haemoglobin ingestion pathway remain unanswered; in consequence, a number of attractive drug targets remain to be exploited. Piero Olliaro and Daniel Goldberg here review the morphology, metabolism and pharmacological disruption of this specialized organelle.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalParasitology Today
Volume11
Issue number8
DOIs
StatePublished - Aug 1995

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