The pharmacogenetics of antiretroviral therapy: A review of studies to date

Erin Quirk, Howard McLeod, William Powderly

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Although the ever-expanding armamentarium of antiretroviral drugs has significantly decreased the morbidity and mortality due to human immunodeficiency virus infection, patients and clinicians are increasingly faced with the problems of inadequate or toxic response to therapy that may be genetically mediated. Significant evidence now exists that interindividual differences, such as efficacy of therapy, hypersensitivity reactions, and metabolic complications as a result of antiretroviral therapy, are in part genetically determined. This article reviews the significant studies published to date in the area of the pharmacogenetics of antiretroviral therapy and summarizes current trends, as well as areas where further research is needed.

Original languageEnglish
Pages (from-to)98-106
Number of pages9
JournalClinical Infectious Diseases
Volume39
Issue number1
DOIs
StatePublished - Jul 1 2004

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