The peroxisome proliferator-activated receptorγ (PPARγ) as a regulator of monocyte/macrophage function

Mercedes Ricote, Jannet T. Huang, John S. Welch, Christopher K. Glass

Research output: Contribution to journalArticle

261 Scopus citations

Abstract

Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors of the nuclear hormone receptor superfamily, which includes the steroid, retinoid, and thyroid hormone receptors. The PPARs can be activated by fatty acids and their eicosanoid metabolites, and have until recently been considered primarily to regulate genes involved in glucose and lipid homeostasis. In the past year there has been an explosive increase in research implicating PPARγ in macrophage biology, cell cycle regulation, and atherosclerosis. This review describes recent insights into the role of PPARγ in the macrophage lineage, and its potential function in the regulation of inflammatory responses and atherosclerosis.

Original languageEnglish
Pages (from-to)733-739
Number of pages7
JournalJournal of Leukocyte Biology
Volume66
Issue number5
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Atherosclerosis
  • Inflammatory response
  • Nuclear receptor
  • Transcription factors

Fingerprint Dive into the research topics of 'The peroxisome proliferator-activated receptorγ (PPARγ) as a regulator of monocyte/macrophage function'. Together they form a unique fingerprint.

  • Cite this