THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE

M. A. Moskowitz; Deborah Rubin; J. Liebschutz; H. N. Munro; T. S. Nowak; R. J. Wurtman

doi:10.1111/j.1471-4159.1977.tb10627.x

THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE

M. A. Moskowitz
, Deborah Rubin
, J. Liebschutz
, H. N. Munro
, T. S. Nowak
, R. J. Wurtman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Abstract— l‐DOPA or d‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.

Original language	English
Pages (from-to)	779-782
Number of pages	4
Journal	Journal of Neurochemistry
Volume	28
Issue number	4
DOIs	https://doi.org/10.1111/j.1471-4159.1977.tb10627.x
State	Published - Apr 1977

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abstract = "Abstract— l‐DOPA or d‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.",

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AU - Wurtman, R. J.

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AB - Abstract— l‐DOPA or d‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.

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THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE

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