THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE

M. A. Moskowitz; Deborah Rubin; J. Liebschutz; H. N. Munro; T. S. Nowak; R. J. Wurtman

doi:10.1111/j.1471-4159.1977.tb10627.x

THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE

M. A. Moskowitz, Deborah Rubin, J. Liebschutz, H. N. Munro, T. S. Nowak, R. J. Wurtman

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Abstract

Abstract— l‐DOPA or d‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.

Original language	English
Pages (from-to)	779-782
Number of pages	4
Journal	Journal of Neurochemistry
Volume	28
Issue number	4
DOIs	https://doi.org/10.1111/j.1471-4159.1977.tb10627.x
State	Published - Apr 1977

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abstract = "Abstract— l‐DOPA or d‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.",

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THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE

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