TY - JOUR
T1 - The Peripheral Metabolism of Parathyroid Hormone
AU - Martin, Kevin J.
AU - Hruska, Keith A.
AU - Freitag, Jeffrey J.
AU - Klahr, Saulo
AU - Slatopolsky, Eduardo
PY - 1979/11/15
Y1 - 1979/11/15
N2 - AFTER the radioimmunoassay for parathyroid hormone (PTH) was introduced by Berson et al. in 1963,1 initial enthusiasm for its clinical application was tempered because widely differing results were reported from several laboratories.2 3 4 5 The overlap of serum levels of immunoreactive PTH (iPTH) between normal subjects and patients with hyperparathyroidism ranged from 0 to 50 per cent. In addition, whereas Reiss and Canterbury3 reported that serum levels of iPTH were not reduced by calcium infusion in patients with parathyroid adenomas, Potts and his coworkers4 found marked suppression of serum iPTH levels in response to induced hypercalcemia in a similar group of patients.
AB - AFTER the radioimmunoassay for parathyroid hormone (PTH) was introduced by Berson et al. in 1963,1 initial enthusiasm for its clinical application was tempered because widely differing results were reported from several laboratories.2 3 4 5 The overlap of serum levels of immunoreactive PTH (iPTH) between normal subjects and patients with hyperparathyroidism ranged from 0 to 50 per cent. In addition, whereas Reiss and Canterbury3 reported that serum levels of iPTH were not reduced by calcium infusion in patients with parathyroid adenomas, Potts and his coworkers4 found marked suppression of serum iPTH levels in response to induced hypercalcemia in a similar group of patients.
UR - http://www.scopus.com/inward/record.url?scp=0018698107&partnerID=8YFLogxK
U2 - 10.1056/NEJM197911153012005
DO - 10.1056/NEJM197911153012005
M3 - Review article
C2 - 386126
AN - SCOPUS:0018698107
SN - 0028-4793
VL - 301
SP - 1092
EP - 1098
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 20
ER -