TY - JOUR
T1 - The pediatric urobiome in genitourinary conditions
T2 - a narrative review
AU - Cole, Elisabeth
AU - Shaikh, Nader
AU - Forster, Catherine S.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to International Pediatric Nephrology Association.
PY - 2022/7
Y1 - 2022/7
N2 - The microbial ecosystem within the bladder that can be measured within the urine, or urobiome, is an emerging field of study with little published data regarding children. However, investigations into urobiome research have the potential to significantly impact the understanding of the pathophysiology of genitourinary conditions, as well as potentially identify novel therapeutics. Therefore, both researchers and clinicians should be aware of pediatric urobiome research. The purpose of this review is to highlight the literature around urobiome research in urinary tract infections, nephrolithiasis, and neurogenic bladder; comment on pediatric-specific considerations when reading and interpreting the urobiome literature; and to identify new potential areas of research.
AB - The microbial ecosystem within the bladder that can be measured within the urine, or urobiome, is an emerging field of study with little published data regarding children. However, investigations into urobiome research have the potential to significantly impact the understanding of the pathophysiology of genitourinary conditions, as well as potentially identify novel therapeutics. Therefore, both researchers and clinicians should be aware of pediatric urobiome research. The purpose of this review is to highlight the literature around urobiome research in urinary tract infections, nephrolithiasis, and neurogenic bladder; comment on pediatric-specific considerations when reading and interpreting the urobiome literature; and to identify new potential areas of research.
KW - Kidney stones
KW - Neurogenic bladder
KW - Urinary tract infections
KW - Urobiome
UR - http://www.scopus.com/inward/record.url?scp=85117093806&partnerID=8YFLogxK
U2 - 10.1007/s00467-021-05274-7
DO - 10.1007/s00467-021-05274-7
M3 - Review article
C2 - 34654953
AN - SCOPUS:85117093806
SN - 0931-041X
VL - 37
SP - 1443
EP - 1452
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 7
ER -