The Pathogenesis of Vascular Calcification in the Chronic Kidney Disease Mineral Bone Disorder: The Links Between Bone and the Vasculature

Keith A. Hruska, Suresh Mathew, Richard J. Lund, Imran Memon, Georges Saab

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Considerable scientific progress in the pathogenesis of vascular calcification that has accrued in recent years is reviewed in this article. Factors regulating mesenchymal cell differentiation and their role in the neointimal calcification of atherosclerosis and the vascular media calcification observed in chronic kidney disease and diabetes are discussed, as is the role of bone regulatory proteins in bone mineralization and vascular calcification. This includes recent studies related to fetuin-A, and the discovery of a new circulating hormone involved in regulating phosphate homeostasis and sensing skeletal hydroxyapatite precipitation. Finally, the relationship between skeletal mineralization and vascular mineralization is discussed in terms of their links, especially through serum phosphate concentrations.

Original languageEnglish
Pages (from-to)156-165
Number of pages10
JournalSeminars in Nephrology
Volume29
Issue number2
DOIs
StatePublished - Mar 2009

Keywords

  • Vascular calcifications
  • cardiovascular disease
  • fetuin-A
  • matrix Gla protein
  • phosphorus
  • vascular smooth muscle
  • vitamin D

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