TY - JOUR
T1 - The Pathogenesis of Vascular Calcification in the Chronic Kidney Disease Mineral Bone Disorder
T2 - The Links Between Bone and the Vasculature
AU - Hruska, Keith A.
AU - Mathew, Suresh
AU - Lund, Richard J.
AU - Memon, Imran
AU - Saab, Georges
PY - 2009/3
Y1 - 2009/3
N2 - Considerable scientific progress in the pathogenesis of vascular calcification that has accrued in recent years is reviewed in this article. Factors regulating mesenchymal cell differentiation and their role in the neointimal calcification of atherosclerosis and the vascular media calcification observed in chronic kidney disease and diabetes are discussed, as is the role of bone regulatory proteins in bone mineralization and vascular calcification. This includes recent studies related to fetuin-A, and the discovery of a new circulating hormone involved in regulating phosphate homeostasis and sensing skeletal hydroxyapatite precipitation. Finally, the relationship between skeletal mineralization and vascular mineralization is discussed in terms of their links, especially through serum phosphate concentrations.
AB - Considerable scientific progress in the pathogenesis of vascular calcification that has accrued in recent years is reviewed in this article. Factors regulating mesenchymal cell differentiation and their role in the neointimal calcification of atherosclerosis and the vascular media calcification observed in chronic kidney disease and diabetes are discussed, as is the role of bone regulatory proteins in bone mineralization and vascular calcification. This includes recent studies related to fetuin-A, and the discovery of a new circulating hormone involved in regulating phosphate homeostasis and sensing skeletal hydroxyapatite precipitation. Finally, the relationship between skeletal mineralization and vascular mineralization is discussed in terms of their links, especially through serum phosphate concentrations.
KW - Vascular calcifications
KW - cardiovascular disease
KW - fetuin-A
KW - matrix Gla protein
KW - phosphorus
KW - vascular smooth muscle
KW - vitamin D
UR - http://www.scopus.com/inward/record.url?scp=64049095508&partnerID=8YFLogxK
U2 - 10.1016/j.semnephrol.2009.01.008
DO - 10.1016/j.semnephrol.2009.01.008
M3 - Article
C2 - 19371806
AN - SCOPUS:64049095508
SN - 0270-9295
VL - 29
SP - 156
EP - 165
JO - Seminars in Nephrology
JF - Seminars in Nephrology
IS - 2
ER -