The Pathogenesis of Resection-Associated Intestinal Adaptation

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After massive small-bowel resection, the remnant bowel compensates by a process termed adaptation. Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The mechanisms/mediators of this important response are multiple. The purpose of this review is to highlight the major basic contributions in elucidating a more comprehensive understanding of this process.

Original languageEnglish
Pages (from-to)429-438
Number of pages10
Issue number4
StatePublished - Jul 1 2016


  • Absorption
  • Adaptation
  • Angiogenesis
  • Apoptosis
  • Epithelium
  • Growth Factors
  • Proliferation
  • Villus


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