The over expression of cathelicidin peptide LL37 in head and neck squamous cell carcinoma: The peptide marker for the prognosis of cancer

Kamaldeep Gill, Bidhu Kalyan Mohanti, Abhay Kumar Singh, Biswajit Mishra, Sharmistha Dey

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The over expression of LL37, an antimicrobial peptide belonging~to the cathelicidin family has implication in the progression of human malignancy but the exact role is still not clear. This study aims to elucidate the correlation of LL37 with Head and Neck Squamous Cell Carcinoma (HNSCC) and the consequences of radiotherapy on it. The LL37 levels were quantified in serum samples of control and HNSCC patients at pre-RT, during-RT and post-RT using a real time Surface Plasmon Resonance technology and ELISA. The LL37 of 50 HNSCC patients was significantly (p< 0.0001) threefold higher than the 25 controls and declined with respect to radiation therapy (p< 0.0001) supporting its candidature as a prognostic marker in HNSCC.

Original languageEnglish
Pages (from-to)125-134
Number of pages10
JournalCancer Biomarkers
Volume10
Issue number3-4
DOIs
StatePublished - 2011

Keywords

  • HNSCC
  • LL37
  • prognostic marker
  • radiation therapy

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