TY - JOUR
T1 - The osteoclast and its unique cytoskeleton
AU - Teitelbaum, Steven L.
PY - 2011/12
Y1 - 2011/12
N2 - The osteoclast cytoskeleton is a unique structure that polarizes the cell's resorptive machinery to the bone-cell interface where it creates an isolated resorptive microenvironment consisting of an actin ring surrounding a ruffled border. This polarization process occurs under the aegis of the αvβ3 integrin in collaboration with the M-CSF receptor, c-Fms. When occupied, αvβ3 activates a canonical signaling complex consisting of c-Src, Syk, Dap12, Slp76, Vav 3, and Rac that permits the cell to spread and form actin rings. Generation of the ruffled border, the cell's resorptive organelle, is an exocytic process wherein synaptotagmin VII mediates fusion of secretory lysosomes to the bone-apposed plasma membrane. Absence of any component of this signaling pathway compromises osteoclast cytoskeletal organization and abridges bone resorption.
AB - The osteoclast cytoskeleton is a unique structure that polarizes the cell's resorptive machinery to the bone-cell interface where it creates an isolated resorptive microenvironment consisting of an actin ring surrounding a ruffled border. This polarization process occurs under the aegis of the αvβ3 integrin in collaboration with the M-CSF receptor, c-Fms. When occupied, αvβ3 activates a canonical signaling complex consisting of c-Src, Syk, Dap12, Slp76, Vav 3, and Rac that permits the cell to spread and form actin rings. Generation of the ruffled border, the cell's resorptive organelle, is an exocytic process wherein synaptotagmin VII mediates fusion of secretory lysosomes to the bone-apposed plasma membrane. Absence of any component of this signaling pathway compromises osteoclast cytoskeletal organization and abridges bone resorption.
KW - Actin ring
KW - Cytoskeleton
KW - Integrin
KW - Osteoclast
UR - http://www.scopus.com/inward/record.url?scp=83755225707&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2011.06283.x
DO - 10.1111/j.1749-6632.2011.06283.x
M3 - Comment/debate
C2 - 22172034
AN - SCOPUS:83755225707
SN - 0077-8923
VL - 1240
SP - 14
EP - 17
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -