TY - JOUR
T1 - The orphan granzymes of humans and mice
AU - Grossman, William J.
AU - Revell, Paula A.
AU - Lu, Zhi Hong
AU - Johnson, Hillary
AU - Bredemeyer, Andrew J.
AU - Ley, Timothy J.
N1 - Funding Information:
This work was supported by a National Institutes of Health training program grant in Developmental Hematology (NICHHD 5T32 H007499), National Institutes of Health grant number DK 49786, and the Alan A and Edith V Wolff professorship in Medicine.
PY - 2003/10
Y1 - 2003/10
N2 - The granzyme/perforin pathway is a central pathway for lymphocyte-mediated killing in both the innate and adaptive immune systems. This pathway is important in a variety of host defenses, including viral clearance and tumor cell killing, and its dysregulation results in several human and rodent diseases. To date, the majority of reports in this field have concentrated on the functions of granzymes A and B. Recent reports, however, suggest that the non-A/non-B 'orphan' granzymes found in both humans and mice are potentially significant. Although the functions of these orphan granzymes have yet to be fully established, initial data suggests their importance in both immune and nonimmune cells.
AB - The granzyme/perforin pathway is a central pathway for lymphocyte-mediated killing in both the innate and adaptive immune systems. This pathway is important in a variety of host defenses, including viral clearance and tumor cell killing, and its dysregulation results in several human and rodent diseases. To date, the majority of reports in this field have concentrated on the functions of granzymes A and B. Recent reports, however, suggest that the non-A/non-B 'orphan' granzymes found in both humans and mice are potentially significant. Although the functions of these orphan granzymes have yet to be fully established, initial data suggests their importance in both immune and nonimmune cells.
UR - http://www.scopus.com/inward/record.url?scp=0141853015&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(03)00099-2
DO - 10.1016/S0952-7915(03)00099-2
M3 - Review article
C2 - 14499263
AN - SCOPUS:0141853015
SN - 0952-7915
VL - 15
SP - 544
EP - 552
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 5
ER -