The orphan granzymes of humans and mice

William J. Grossman, Paula A. Revell, Zhi Hong Lu, Hillary Johnson, Andrew J. Bredemeyer, Timothy J. Ley

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations

Abstract

The granzyme/perforin pathway is a central pathway for lymphocyte-mediated killing in both the innate and adaptive immune systems. This pathway is important in a variety of host defenses, including viral clearance and tumor cell killing, and its dysregulation results in several human and rodent diseases. To date, the majority of reports in this field have concentrated on the functions of granzymes A and B. Recent reports, however, suggest that the non-A/non-B 'orphan' granzymes found in both humans and mice are potentially significant. Although the functions of these orphan granzymes have yet to be fully established, initial data suggests their importance in both immune and nonimmune cells.

Original languageEnglish
Pages (from-to)544-552
Number of pages9
JournalCurrent Opinion in Immunology
Volume15
Issue number5
DOIs
StatePublished - Oct 2003

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