The opposing forces of the intestinal microbiome and the emerging pathobiome

Jennifer Defazio, Irma D. Fleming, Baddr Shakhsheer, Olga Zaborina, John C. Alverdy

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


This article summarizes emerging concepts on the role of the intestinal microbiome in surgical patients. Revolutionary research over the past decade has shown that human beings live in close and constant contact with boundless communities of microbes. Recent innovations in the study of the human microbiome are reviewed. To demonstrate the applicability of these studies to surgical disease, the authors discuss what is known about the role of microbes in the pathogenesis of perioperative complications. Enhanced awareness of the human microbiome will empower clinicians to adopt novel practices in the prevention and treatment of a variety of surgical conditions.

Original languageEnglish
Pages (from-to)1151-1161
Number of pages11
JournalSurgical Clinics of North America
Issue number6
StatePublished - 2014


  • Anastomotic leak
  • Bacteria
  • Infection
  • Metabolomics
  • Microbiome
  • Proteomics
  • Sepsis


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