The ontogeny of immunoreactive β-endorphin and β-lipotropin in the rat ovary

Michael L. Adams, Theodore J. Cicero

Research output: Contribution to journalArticle

Abstract

We have investigated the ontogeny of, and the effect of hypophysectomy on, immunoreactive β-endorphin in rat ovaries. Total levels rose with ovarian weight from nondetectable levels at 5 days of age to approximately 0.15 pmol/ovary at 80 days; thereafter, the levels remained constant through 201 days of age. Hypophysectomy decreased both ovarian weight and the total content of immunoreactive β-endorphin, but the concentration per weight was not significantly altered. Most of the immunoreactive β-endorphin before puberty chromatographed like authentic β-endorphin, but after puberty most chromatographed like β-lipotropin. Hypophysectomy did not alter this chromatographic pattern.

Original languageEnglish
Pages (from-to)1171-1176
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume159
Issue number3
DOIs
StatePublished - Mar 31 1989

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