TY - JOUR
T1 - The ontogeny of immunoreactive β-endorphin and β-lipotropin in the rat ovary
AU - Adams, Michael L.
AU - Cicero, Theodore J.
N1 - Funding Information:
This research was supported in part by USPHS grants DA-03833 from the National Institute on Drug Abuse; AA-07144, AA-03839, and AA-07466 from the National Institute on Alcohol Abuse and Alcoholism and MH-14677 from the National Institute of Mental Health. Theodore J. Cicero is a recipient of Researce Scientist Award DA-00095 from the National Institute of Drug Abuse.
PY - 1989/3/31
Y1 - 1989/3/31
N2 - We have investigated the ontogeny of, and the effect of hypophysectomy on, immunoreactive β-endorphin in rat ovaries. Total levels rose with ovarian weight from nondetectable levels at 5 days of age to approximately 0.15 pmol/ovary at 80 days; thereafter, the levels remained constant through 201 days of age. Hypophysectomy decreased both ovarian weight and the total content of immunoreactive β-endorphin, but the concentration per weight was not significantly altered. Most of the immunoreactive β-endorphin before puberty chromatographed like authentic β-endorphin, but after puberty most chromatographed like β-lipotropin. Hypophysectomy did not alter this chromatographic pattern.
AB - We have investigated the ontogeny of, and the effect of hypophysectomy on, immunoreactive β-endorphin in rat ovaries. Total levels rose with ovarian weight from nondetectable levels at 5 days of age to approximately 0.15 pmol/ovary at 80 days; thereafter, the levels remained constant through 201 days of age. Hypophysectomy decreased both ovarian weight and the total content of immunoreactive β-endorphin, but the concentration per weight was not significantly altered. Most of the immunoreactive β-endorphin before puberty chromatographed like authentic β-endorphin, but after puberty most chromatographed like β-lipotropin. Hypophysectomy did not alter this chromatographic pattern.
UR - http://www.scopus.com/inward/record.url?scp=0024521951&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(89)92233-X
DO - 10.1016/0006-291X(89)92233-X
M3 - Article
C2 - 2522774
AN - SCOPUS:0024521951
SN - 0006-291X
VL - 159
SP - 1171
EP - 1176
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -