The ocular hypertension treatment study: Topical medication delays or prevents primary open-angle glaucoma in African American individuals

Eve J. Higginbotham, Mae O. Gordon, Julia A. Beiser, Michael V. Drake, G. Richard Bennett, M. Roy Wilson, Michael A. Kass

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

Background: The prevalence of glaucoma is higher in African American individuals than in white individuals. Objective: To report the safety and efficacy of topical ocular hypotensive medication in delaying or preventing the onset of primary open-angle glaucoma (POAG) among African American participants in the Ocular Hypertension Treatment Study. Methods: Eligibility criteria included age between 40 and 80 years, intraocular pressure between 24 and 32 mm Hg in one eye and between 21 and 32 mm Hg in the other eye, and no evidence of glaucomatous structural or functional damage by standard clinical measures. Participants were randomized to either the observation group or medication group. Of the 1636 participants randomized, 408 were self-identified as African American. Main Outcome Measure: The primary outcome was the development of reproducible visual field abnormality and/or reproducible optic disc deterioration attributed to POAG. Results: Among African American participants, 17 (8.4%) of 203 in the medication group developed POAG during the study (median follow-up, 78 months) compared with 33 (16.1%) of 205 participants in the observation group (hazard ratio, 0.50; 95% confidence interval, 0.28-0.90; P=.02). Conclusion: Topical ocular hypotensive therapy is effective in delaying or preventing the onset of POAG in African American individuals who have ocular hypertension.

Original languageEnglish
Pages (from-to)813-820
Number of pages8
JournalArchives of Ophthalmology
Volume122
Issue number6
DOIs
StatePublished - Jun 2004

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