TY - JOUR
T1 - The Ocular Hypertension Treatment Study
T2 - Baseline factors that predict the onset of primary open-angle glaucoma
AU - Gordon, Mae O.
AU - Beiser, Julia A.
AU - Brandt, James D.
AU - Heuer, Dale K.
AU - Higginbotham, Eve J.
AU - Johnson, Chris A.
AU - Keltner, John L.
AU - Philip Miller, J.
AU - Parrish, Richard K.
AU - Roy Wilson, M.
AU - Kass, Michael A.
PY - 2002
Y1 - 2002
N2 - Background: The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. Objective: To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG. Methods: Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG. Results: In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement. Conclusions: Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.
AB - Background: The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. Objective: To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG. Methods: Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG. Results: In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement. Conclusions: Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.
UR - http://www.scopus.com/inward/record.url?scp=0036272299&partnerID=8YFLogxK
U2 - 10.1001/archopht.120.6.714
DO - 10.1001/archopht.120.6.714
M3 - Article
C2 - 12049575
AN - SCOPUS:0036272299
SN - 0003-9950
VL - 120
SP - 714
EP - 720
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 6
ER -