The nucleosome remodeling and deacetylase complex in development and disease

Jeannine Basta; Michael Rauchman

doi:10.1016/j.trsl.2014.05.003

The nucleosome remodeling and deacetylase complex in development and disease

Research output: Contribution to journal › Review article › peer-review

Abstract

The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

Original language	English
Pages (from-to)	36-47
Number of pages	12
Journal	Translational Research
Volume	165
Issue number	1
DOIs	https://doi.org/10.1016/j.trsl.2014.05.003
State	Published - Jan 1 2015

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abstract = "The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.",

author = "Jeannine Basta and Michael Rauchman",

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AU - Rauchman, Michael

N1 - Funding Information: The authors would like to acknowledge support from National Institute of Diabetes and Digestive and Kidney Diseases , the American Heart Association , and the March of Dimes .

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N2 - The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

AB - The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

UR - https://www.scopus.com/pages/publications/84919875360

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The nucleosome remodeling and deacetylase complex in development and disease

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