The Nucleosome Remodeling and Deacetylase Complex in Development and Disease

J. Basta; M. Rauchman

doi:10.1016/B978-0-12-800802-7.00003-4

The Nucleosome Remodeling and Deacetylase Complex in Development and Disease

J. Basta, M. Rauchman

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Scopus citations

Abstract

The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

Original language	English
Title of host publication	Translating Epigenetics to the Clinic
Publisher	Elsevier Inc.
Pages	37-72
Number of pages	36
ISBN (Print)	9780128008027
DOIs	https://doi.org/10.1016/B978-0-12-800802-7.00003-4
State	Published - Jan 4 2017

Keywords

Cancer
Cell differentiation
Chromatin remodeling
DNA damage repair
Embryonic development
Embryonic stem cell
Gene expression
NuRD complex
Pluripotency

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10.1016/B978-0-12-800802-7.00003-4

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abstract = "The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.",

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AB - The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.

KW - Cancer

KW - Cell differentiation

KW - Chromatin remodeling

KW - DNA damage repair

KW - Embryonic development

KW - Embryonic stem cell

KW - Gene expression

KW - NuRD complex

KW - Pluripotency

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SN - 9780128008027

SP - 37

EP - 72

BT - Translating Epigenetics to the Clinic

PB - Elsevier Inc.

ER -

The Nucleosome Remodeling and Deacetylase Complex in Development and Disease

Abstract

Keywords

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