TY - JOUR
T1 - The nucleosome remodeling and deacetylase complex in development and disease
AU - Basta, Jeannine
AU - Rauchman, Michael
N1 - Funding Information:
The authors would like to acknowledge support from National Institute of Diabetes and Digestive and Kidney Diseases , the American Heart Association , and the March of Dimes .
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.
AB - The nucleosome remodeling and deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity, and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis, and accelerated aging. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.
UR - http://www.scopus.com/inward/record.url?scp=84919875360&partnerID=8YFLogxK
U2 - 10.1016/j.trsl.2014.05.003
DO - 10.1016/j.trsl.2014.05.003
M3 - Review article
C2 - 24880148
AN - SCOPUS:84919875360
SN - 1931-5244
VL - 165
SP - 36
EP - 47
JO - Translational Research
JF - Translational Research
IS - 1
ER -