The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-related protein that functions as a tumor suppressor. We found that merlin mediates contact inhibition of growth through signals from the extracellular matrix. At high cell density, merlin becomes hypo-phosphorylated and inhibits cell growth in response to hyaluronate (HA), a mucopolysaccharide that surrounds cells. Merlin's growth-inhibitory activity depends on specific interaction with the cytoplasmic tail of CD44, a transmembrane HA receptor. At low cell density, merlin is phosphorylated, growth permissive, and exists in a complex with ezrin, moesin, and CD44. These data indicate that merlin and CD44 form a molecular switch that specifies cell growth arrest or proliferation.

Original languageEnglish
Pages (from-to)968-980
Number of pages13
JournalGenes and Development
Issue number8
StatePublished - Apr 15 2001


  • CD44
  • ERM
  • Ezrin
  • Hyaluronate
  • NF2
  • Schwann cells


Dive into the research topics of 'The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44'. Together they form a unique fingerprint.

Cite this