TY - JOUR
T1 - The new chassis in the flask
T2 - Advances in Vibrio natriegens biotechnology research
AU - Lima, Matthew
AU - Muddana, Charandatta
AU - Xiao, Zhengyang
AU - Bandyopadhyay, Anindita
AU - Wangikar, Pramod P.
AU - Pakrasi, Himadri B.
AU - Tang, Yinjie J.
N1 - Publisher Copyright:
© 2024
PY - 2024/12
Y1 - 2024/12
N2 - Biotechnology has been built on the foundation of a small handful of well characterized and well-engineered organisms. Recent years have seen a breakout performer gain attention as a new entrant into the bioengineering toolbox: Vibrio natriegens. This review covers recent research efforts into making V. natriegens a biotechnology platform, using a large language model (LLM) and knowledge graph to expedite the literature survey process. Scientists have made advancements in research pertaining to the fundamental metabolic characteristics of V. natriegens, development and characterization of synthetic biology tools, systems biology analysis and metabolic modeling, bioproduction and metabolic engineering, and microbial ecology. Each of these subcategories has relevance to the future of V. natriegens for bioengineering applications. In this review, we cover these recent advancements and offer context for the impact they may have on the field, highlighting benefits and drawbacks of using this organism. From examining the recent bioengineering research, it appears that V. natriegens is on the precipice of becoming a platform bacterium for the future of biotechnology.
AB - Biotechnology has been built on the foundation of a small handful of well characterized and well-engineered organisms. Recent years have seen a breakout performer gain attention as a new entrant into the bioengineering toolbox: Vibrio natriegens. This review covers recent research efforts into making V. natriegens a biotechnology platform, using a large language model (LLM) and knowledge graph to expedite the literature survey process. Scientists have made advancements in research pertaining to the fundamental metabolic characteristics of V. natriegens, development and characterization of synthetic biology tools, systems biology analysis and metabolic modeling, bioproduction and metabolic engineering, and microbial ecology. Each of these subcategories has relevance to the future of V. natriegens for bioengineering applications. In this review, we cover these recent advancements and offer context for the impact they may have on the field, highlighting benefits and drawbacks of using this organism. From examining the recent bioengineering research, it appears that V. natriegens is on the precipice of becoming a platform bacterium for the future of biotechnology.
KW - Biomanufacturing
KW - Genome scale model
KW - Knowledge graph
KW - Large language model
KW - Synthetic biology
KW - Systems biology
UR - http://www.scopus.com/inward/record.url?scp=85206177890&partnerID=8YFLogxK
U2 - 10.1016/j.biotechadv.2024.108464
DO - 10.1016/j.biotechadv.2024.108464
M3 - Review article
C2 - 39389280
AN - SCOPUS:85206177890
SN - 0734-9750
VL - 77
JO - Biotechnology Advances
JF - Biotechnology Advances
M1 - 108464
ER -