The neuromuscular blocking effect of doxacurium chloride during isoflurane anaesthesia

D. J. Murray, M. D. Sokoll, W. W. Choi, M. P. Mehta, R. B. Forbes, S. D. Gergis

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Doxacurium, a new long-acting neuromuscular blocking drug, was administered to 45 patients to assess the neuromuscular profile of this drug during isoflurane anaesthesia. Using a mechanical force-displacement transducer to assess neuromuscular block, the ED50 and ED95 for doxacurium during 60% nitrous oxide and 0.7% end-tidal isoflurane concentrations were estimated to be 9 and 16 μg kg-1, respectively. When doxacurium was administered during a stable level of isoflurane anaesthesia, neuromuscular blocking doses were reduced by one-third in comparison to neuromuscular requirements during nitrous oxide and narcotic anaesthesia. As with other non-depolarizing blocking agents, the onset of neuromuscular blockade with doxacurium was accelerated during isoflurane anaesthesia.

Original languageEnglish
Pages (from-to)395-402
Number of pages8
JournalEuropean journal of anaesthesiology
Issue number5
StatePublished - Jan 1 1990


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