TY - JOUR
T1 - The neuroimmune axis in skin sensation, inflammation, and immunity
AU - Trier, Anna M.
AU - Mack, Madison R.
AU - Kim, Brian S.
N1 - Funding Information:
This work was supported by grants from the National Institute of Arthritis and Musculoskel-etal and Skin Diseases at the National Institutes of Health (NIH; K08AR065577 and R01AR070116), the American Skin Association, a Doris Duke Charitable Foundation Clinical Scientist Development Award, and LEO Pharma. A.M.T. is supported by a grant from the National Institute of Allergy and Infectious Diseases at the NIH (T32AI716340).
Funding Information:
Clinical Scientist Development Award, and LEO Pharma. A.M.T. is supported by a grant from the National Institute of Allergy and Infectious Diseases at the NIH (T32AI716340).
Funding Information:
This work was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health (NIH; K08AR065577 and R01AR070116), the American Skin Association, a Doris Duke Charitable Foundation
Publisher Copyright:
Copyright © 2019 by The American Association of Immunologists, Inc. All rights reserved.
PY - 2019/5/15
Y1 - 2019/5/15
N2 - Although connections between the immune and nervous systems have long been recognized, the precise mechanisms that underlie this relationship are just starting to be elucidated. Advances in sensory biology have unveiled novel mechanisms by which inflammatory cytokines promote itch and pain sensations to coordinate host-protective behavioral responses. Conversely, new evidence has emphasized the importance of immune cell regulation by sensory neurons. By focusing on itch biology and how it has been informed by the more established field of pain research, we highlight recent interdisciplinary studies that demonstrate how novel neuroimmune interactions underlie a diversity of sensory, inflammatory, and infectious diseases.
AB - Although connections between the immune and nervous systems have long been recognized, the precise mechanisms that underlie this relationship are just starting to be elucidated. Advances in sensory biology have unveiled novel mechanisms by which inflammatory cytokines promote itch and pain sensations to coordinate host-protective behavioral responses. Conversely, new evidence has emphasized the importance of immune cell regulation by sensory neurons. By focusing on itch biology and how it has been informed by the more established field of pain research, we highlight recent interdisciplinary studies that demonstrate how novel neuroimmune interactions underlie a diversity of sensory, inflammatory, and infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=85065656958&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1801473
DO - 10.4049/jimmunol.1801473
M3 - Review article
C2 - 31061146
AN - SCOPUS:85065656958
SN - 0022-1767
VL - 202
SP - 2829
EP - 2835
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -