The neural substrates of recollection and familiarity

A. P. Yonelinas, N. E.A. Kroll, I. G. Dobbins, M. Lazzara, R. T. Knight

Research output: Contribution to journalShort surveypeer-review


Aggleton and Brown argue that a hippocampal-anterior thalamic system supports the 'recollection' of contextual information about previous events, and that a separate perirhinal-medial dorsal thalamic system supports detection of stimulus 'familiarity.' Although there is a growing body of human literature that is in agreement with these claims, when recollection and familiarity have been examined in amnesics using the process dissociation or the remember/know procedures, the results do not seem to provide consistent support. We reexamine these studies and describe the results of an additional experiment using a receiver operating characteristic (ROC) technique. The results of the reanalysis and the ROC experiment are consistent with Aggleton and Brown's proposal. Patients with damage to both regions exhibit severe deficits in recollection and smaller, but consistent, deficits in familiarity.

Original languageEnglish
Pages (from-to)468-469
Number of pages2
JournalBehavioral and Brain Sciences
Issue number3
StatePublished - 1999


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