The nerve allograft response - an experimental model in the rat

S. E. Mackinnon, A. R. Hudson, R. E. Falk, D. A. Hunter

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

The nerve allograft response in a rat model is presented. The Lewis rat (RTI1) served as the recipient animal while Fischer rats (RTI1) and ACI rats (RTIa) provided the donor nerve allografts. A Lewis/Lewis autograft group was used as the control group. Histological and electrophysiological measurements of nerve regeneration were assessed at 5 months. While good regeneration was noted in the autograft and matched allograft groups, regeneration across the unmatched allograft was poor. The degree of nerve regeneration (as measured with histological and electrophysiological values) correlated well with previous immunological studies and would support the use of this model for future investigation of the nerve allograft response in the rat.

Original languageEnglish
Pages (from-to)334-339
Number of pages6
JournalAnnals of Plastic Surgery
Volume14
Issue number4
DOIs
StatePublished - Jan 1 1985

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