The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response

Stephane Daffis; Helen M. Lazear; Wen Jun Liu; Michelle Audsley; Michael Engle; Alexander A. Khromykh; Michael S. Diamond

doi:10.1128/JVI.00232-11

The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response

Stephane Daffis, Helen M. Lazear, Wen Jun Liu, Michelle Audsley, Michael Engle, Alexander A. Khromykh, Michael S. Diamond

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53 Scopus citations

Abstract

The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNVKUN), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNVKUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNVKUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNVKUN is attenuated primarily through its enhanced restriction by type I interferon- and IRF-3-dependent mechanisms.

Original language	English
Pages (from-to)	5664-5668
Number of pages	5
Journal	Journal of virology
Volume	85
Issue number	11
DOIs	https://doi.org/10.1128/JVI.00232-11
State	Published - Jun 2011

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abstract = "The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNVKUN), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNVKUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNVKUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNVKUN is attenuated primarily through its enhanced restriction by type I interferon- and IRF-3-dependent mechanisms.",

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AU - Daffis, Stephane

AU - Lazear, Helen M.

AU - Liu, Wen Jun

AU - Audsley, Michelle

AU - Engle, Michael

AU - Khromykh, Alexander A.

AU - Diamond, Michael S.

PY - 2011/6

Y1 - 2011/6

N2 - The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNVKUN), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNVKUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNVKUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNVKUN is attenuated primarily through its enhanced restriction by type I interferon- and IRF-3-dependent mechanisms.

AB - The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNVKUN), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNVKUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNVKUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNVKUN is attenuated primarily through its enhanced restriction by type I interferon- and IRF-3-dependent mechanisms.

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SP - 5664

EP - 5668

JO - Journal of virology

JF - Journal of virology

IS - 11

ER -

The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response

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