TY - JOUR
T1 - The natural killer gene complex
T2 - A genetic basis for understanding natural killer cell function and innate immunity
AU - Brown, M. G.
AU - Scalzo, A. A.
AU - Matsumoto, K.
AU - Yokoyama, W. M.
PY - 1997/2/24
Y1 - 1997/2/24
N2 - The natural killer gene complex encodes proteins, some of which are structurally unrelated, that impact on NK-cell function. Detailed analyses have indicated that these molecules are involved in NK-cell recognition, activation, and inhibition. The importance of this genomic region is highlighted by studies indicating that NKC-associated genes significantly influence NK cell-mediated innate host defense against life-threatening pathogens and that the NKC is conserved among diverse species. Thus, further elucidation of the NKC and its gene products will provide a genetic basis for understanding innate immunity and NK-cell activity at the molecular level.
AB - The natural killer gene complex encodes proteins, some of which are structurally unrelated, that impact on NK-cell function. Detailed analyses have indicated that these molecules are involved in NK-cell recognition, activation, and inhibition. The importance of this genomic region is highlighted by studies indicating that NKC-associated genes significantly influence NK cell-mediated innate host defense against life-threatening pathogens and that the NKC is conserved among diverse species. Thus, further elucidation of the NKC and its gene products will provide a genetic basis for understanding innate immunity and NK-cell activity at the molecular level.
UR - http://www.scopus.com/inward/record.url?scp=0031049085&partnerID=8YFLogxK
U2 - 10.1111/j.1600-065X.1997.tb00939.x
DO - 10.1111/j.1600-065X.1997.tb00939.x
M3 - Review article
C2 - 9059882
AN - SCOPUS:0031049085
SN - 0105-2896
VL - 155
SP - 53
EP - 65
JO - Immunological Reviews
JF - Immunological Reviews
ER -