The natural killer gene complex: A genetic basis for understanding natural killer cell function and innate immunity

M. G. Brown, A. A. Scalzo, K. Matsumoto, W. M. Yokoyama

Research output: Contribution to journalReview article

146 Scopus citations

Abstract

The natural killer gene complex encodes proteins, some of which are structurally unrelated, that impact on NK-cell function. Detailed analyses have indicated that these molecules are involved in NK-cell recognition, activation, and inhibition. The importance of this genomic region is highlighted by studies indicating that NKC-associated genes significantly influence NK cell-mediated innate host defense against life-threatening pathogens and that the NKC is conserved among diverse species. Thus, further elucidation of the NKC and its gene products will provide a genetic basis for understanding innate immunity and NK-cell activity at the molecular level.

Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalImmunological Reviews
Volume155
DOIs
StatePublished - Feb 24 1997

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