The natural history of a novel, systemic, disseminated model of syngeneic mouse B-cell lymphoma

Michael J. Passineau, Gene P. Siegal, Maaike Everts, Alexander Pereboev, Darshana Jhala, Minghui Wang, Zeng B. Zhu, Sangae Kim Park, David T. Curiel, Gina M. Nelson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Lymphomas and leukemias, neoplasms of hematopoetic lineage, pose unique challenges that require novel treatment paradigms. The inter-relationship between the immune system and the neoplastic lesion in these diseases dictates that, to evaluate novel therapies, models are needed that mimic human disease in an immunocompetent host. In the present study, we describe a disseminated, syngeneic model of B-cell lymphoma in the Balb/c mouse based upon the A20 cell line. This model mimics aspects of diffuse large B-cell lymphomas in humans, and recapitulates paraspinous tumor growth, bone destruction and nerve root compression, which may complicate disseminated disease. Furthermore, this tumor expresses a key marker of interest, CD40, which is a candidate for tumor-specific vector targeting via current modalities. The present study therefore describes a high-fidelity model of disseminated lymphoma with implications for novel targeted therapeutics.

Original languageEnglish
Pages (from-to)1627-1638
Number of pages12
JournalLeukemia and Lymphoma
Issue number11
StatePublished - Nov 2005


  • B-cell lymphoma
  • CD40
  • Gene therapy
  • Syngeneic model


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